Inflammation in obesity, diabetes, and related disorders

TV Rohm, DT Meier, JM Olefsky, MY Donath - Immunity, 2022 - cell.com
Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

[HTML][HTML] The role of inflammation in diabetes: current concepts and future perspectives

S Tsalamandris, AS Antonopoulos… - European cardiology …, 2019 - ncbi.nlm.nih.gov
Diabetes is a complex metabolic disorder affecting the glucose status of the human body.
Chronic hyperglycaemia related to diabetes is associated with end organ failure. The clinical …

Muscle–organ crosstalk: the emerging roles of myokines

MCK Severinsen, BK Pedersen - Endocrine reviews, 2020 - academic.oup.com
Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …

Macrophage biology in development, homeostasis and disease

TA Wynn, A Chawla, JW Pollard - Nature, 2013 - nature.com
Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues
and show great functional diversity. They have roles in development, homeostasis, tissue …

Type 2 diabetes as an inflammatory disease

MY Donath, SE Shoelson - Nature reviews immunology, 2011 - nature.com
Components of the immune system are altered in obesity and type 2 diabetes (T2D), with the
most apparent changes occurring in adipose tissue, the liver, pancreatic islets, the …

Inflammatory mechanisms in obesity

MF Gregor, GS Hotamisligil - Annual review of immunology, 2011 - annualreviews.org
The modern rise in obesity and its strong association with insulin resistance and type 2
diabetes have elicited interest in the underlying mechanisms of these pathologies. The …

[HTML][HTML] Inflammatory links between obesity and metabolic disease

CN Lumeng, AR Saltiel - The Journal of clinical …, 2011 - Am Soc Clin Investig
The obesity epidemic has forced us to evaluate the role of inflammation in the health
complications of obesity. This has led to a convergence of the fields of immunology and …

Obesity, inflammation, toll-like receptor 4 and fatty acids

MM Rogero, PC Calder - Nutrients, 2018 - mdpi.com
Obesity leads to an inflammatory condition that is directly involved in the etiology of
cardiovascular diseases, type 2 diabetes mellitus, and certain types of cancer. The classic …

Relationship between oxidative stress, ER stress, and inflammation in type 2 diabetes: the battle continues

E Burgos-Morón, Z Abad-Jiménez… - Journal of clinical …, 2019 - mdpi.com
Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin
resistance in which oxidative stress is thought to be a primary cause. Considering that …