Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …

Homologous recombination (HR) performs crucial functions including DNA repair,
segregation of homologous chromosomes, propagation of genetic diversity, and …

Helicases are molecular motor proteins that couple the hydrolysis of NTP to nucleic acid
unwinding. The growing number of DNA helicases implicated in human disease suggests …

In a lifetime, a human being synthesizes approximately 2× 1016 meters of DNA, a distance
that corresponds to 130,000 times the distance between the Earth and the Sun. This …

The eukaryotic cell cycle is conventionally viewed as comprising several discrete steps,
each of which must be completed before the next one is initiated. However, emerging …

Two eukaryotic pathways for processing double-strand breaks (DSBs) as crossovers have
been described, one dependent on the MutL homologs Mlh1 and Mlh3, and the other on the …

Stalled DNA replication fork restart after stress as orchestrated by ATR kinase, BLM
helicase, and structure-specific nucleases enables replication, cell survival, and genome …

Cells of all living organisms have evolved complex mechanisms that serve to stabilise,
repair and restart stalled, blocked and broken replication forks. The heterodimeric Mus81 …

Telomerase-negative cancer cells maintain their telomeres through the alternative
lengthening of telomeres (ALT) pathway,,. Although a growing body of evidence …

Bloom's syndrome (BS) is an autosomal recessive disorder characterized by growth
retardation, cancer predisposition, and sterility. BS mutated (Blm), the gene mutated in BS …