Imaging calcium in neurons
Calcium ions generate versatile intracellular signals that control key functions in all types of
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …
Experimental evidence for sparse firing in the neocortex
The advent of unbiased recording and imaging techniques to evaluate firing activity across
neocortical neurons has revealed substantial heterogeneity in response properties in vivo …
neocortical neurons has revealed substantial heterogeneity in response properties in vivo …
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease
B Zeitler, S Froelich, K Marlen, DA Shivak, Q Yu, D Li… - Nature medicine, 2019 - nature.com
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic …
a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic …
Reorganization of cortical population activity imaged throughout long-term sensory deprivation
Sensory maps are reshaped by experience. It is unknown how map plasticity occurs in vivo
in functionally diverse neuronal populations because activity of the same cells has not been …
in functionally diverse neuronal populations because activity of the same cells has not been …
Putting a finishing touch on GECIs
More than a decade ago genetically encoded calcium indicators (GECIs) entered the stage
as new promising tools to image calcium dynamics and neuronal activity in living tissues …
as new promising tools to image calcium dynamics and neuronal activity in living tissues …
Mesoscale transcranial spontaneous activity map** in GCaMP3 transgenic mice reveals extensive reciprocal connections between areas of somatomotor cortex
MP Vanni, TH Murphy - Journal of Neuroscience, 2014 - Soc Neuroscience
Transgenic mice expressing genetically encoded activity indicators are an attractive means
of map** mesoscopic regional functional cortical connectivity given widespread stable …
of map** mesoscopic regional functional cortical connectivity given widespread stable …
[HTML][HTML] Single-shot photoacoustic microscopy of hemoglobin concentration, oxygen saturation, and blood flow in sub-microseconds
We present fast functional optical-resolution photoacoustic microscopy (OR-PAM) that can
simultaneously image hemoglobin concentration, blood flow speed, and oxygen saturation …
simultaneously image hemoglobin concentration, blood flow speed, and oxygen saturation …
Imaging the awake visual cortex with a genetically encoded voltage indicator
Genetically encoded voltage indicators (GEVIs) promise to reveal the membrane potential of
genetically targeted neuronal populations through noninvasive, chronic imaging of large …
genetically targeted neuronal populations through noninvasive, chronic imaging of large …
Long-range population dynamics of anatomically defined neocortical networks
The coordination of activity across neocortical areas is essential for mammalian brain
function. Understanding this process requires simultaneous functional measurements …
function. Understanding this process requires simultaneous functional measurements …
In vivo Large-Scale Cortical Map** Using Channelrhodopsin-2 Stimulation in Transgenic Mice Reveals Asymmetric and Reciprocal Relationships between Cortical …
We have mapped intracortical activity in vivo independent of sensory input using arbitrary
point channelrhodopsin-2 (ChR2) stimulation and regional voltage sensitive dye imaging in …
point channelrhodopsin-2 (ChR2) stimulation and regional voltage sensitive dye imaging in …