Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications

MZ Totland, NL Rasmussen, LM Knudsen… - Cellular and Molecular …, 2020 - Springer
Gap junctions consist of arrays of intercellular channels that enable adjacent cells to
communicate both electrically and metabolically. Gap junctions have a wide diversity of …

[HTML][HTML] Astrocytic modulation of neuronal excitability through K+ spatial buffering

A Bellot-Saez, O Kékesi, JW Morley… - … & Biobehavioral Reviews, 2017 - Elsevier
The human brain contains two major cell populations, neurons and glia. While neurons are
electrically excitable and capable of discharging short voltage pulses known as action …

The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes

MS Nielsen, CJM van Opbergen… - Physiological …, 2023 - journals.physiology.org
The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Connexins in the heart: regulation, function and involvement in cardiac disease

A Rodríguez-Sinovas, JA Sánchez… - International journal of …, 2021 - mdpi.com
Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

[HTML][HTML] The connexin 43 C-terminus: A tail of many tales

E Leithe, M Mesnil, T Aasen - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Connexins are chordate gap junction channel proteins that, by enabling direct
communication between the cytosols of adjacent cells, create a unique cell signalling …

Role of connexin 43 in different forms of intercellular communication–gap junctions, extracellular vesicles and tunnelling nanotubes

TM Ribeiro-Rodrigues… - Journal of cell …, 2017 - journals.biologists.com
Communication is important to ensure the correct and efficient flow of information, which is
required to sustain active social networks. A fine-tuned communication between cells is vital …

Connexins: synthesis, post-translational modifications, and trafficking in health and disease

T Aasen, S Johnstone, L Vidal-Brime, KS Lynn… - International journal of …, 2018 - mdpi.com
Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate
direct intercellular communication, a critical feature for the development, function, and …

Regulation of gap junction channels and hemichannels by phosphorylation and redox changes: a revision

K Pogoda, P Kameritsch, MA Retamal, JL Vega - BMC cell biology, 2016 - Springer
Post-translational modifications of connexins play an important role in the regulation of gap
junction and hemichannel permeability. The prerequisite for the formation of functional gap …

Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targets

K Andelova, T Egan Benova… - International Journal of …, 2020 - mdpi.com
Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts
and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal …

Protein–protein interactions with connexin 43: Regulation and function

PL Sorgen, AJ Trease, G Spagnol, M Delmar… - International journal of …, 2018 - mdpi.com
Connexins are integral membrane building blocks that form gap junctions, enabling direct
cytoplasmic exchange of ions and low-molecular-mass metabolites between adjacent cells …