Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions
Z Megyesfalvi, CM Gay, H Popper… - CA: a cancer journal …, 2023 - Wiley Online Library
Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity.
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …
Small-cell lung cancer
Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is marked by
an exceptionally high proliferative rate, strong predilection for early metastasis and poor …
an exceptionally high proliferative rate, strong predilection for early metastasis and poor …
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data
Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective
therapies are urgently needed. Several lines of evidence, from SCLC primary human …
therapies are urgently needed. Several lines of evidence, from SCLC primary human …
[HTML][HTML] MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate
Small cell lung cancer (SCLC) is a neuroendocrine tumor treated clinically as a single
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …
Small-cell lung cancer: what we know, what we need to know and the path forward
Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung
cancers and is pathologically, molecularly, biologically and clinically very different from other …
cancers and is pathologically, molecularly, biologically and clinically very different from other …
An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer
ML Burr, CE Sparbier, KL Chan, YC Chan… - Cancer cell, 2019 - cell.com
Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy
resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved …
resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved …
Brain metastasis
Brain metastasis, which commonly arises in patients with lung cancer, breast cancer and
melanoma, is associated with poor survival outcomes and poses distinct clinical challenges …
melanoma, is associated with poor survival outcomes and poses distinct clinical challenges …
[HTML][HTML] BACH1 stabilization by antioxidants stimulates lung cancer metastasis
For tumors to progress efficiently, cancer cells must overcome barriers of oxidative stress.
Although dietary antioxidant supplementation or activation of endogenous antioxidants by …
Although dietary antioxidant supplementation or activation of endogenous antioxidants by …
Binary pan-cancer classes with distinct vulnerabilities defined by pro-or anti-cancer YAP/TEAD activity
Cancer heterogeneity impacts therapeutic response, driving efforts to discover over-arching
rules that supersede variability. Here, we define pan-cancer binary classes based on distinct …
rules that supersede variability. Here, we define pan-cancer binary classes based on distinct …
Comprehensive genomic profiles of small cell lung cancer
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the
deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation …
deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation …