The oral administration of therapeutic peptides and proteins is favoured from a patient and
commercial point of view. In order to reach the systemic circulation after oral administration …

Hydrophobic ion pairing has emerged as a method to modulate the solubility of charged
hydrophilic molecules ranging in class from small molecules to large enzymes. Charged …

The application of permeation enhancers (PEs) to improve transport of poorly absorbed
active pharmaceutical ingredients across the intestinal epithelium is a widely tested …

Since the development of self-emulsifying drug delivery systems (SEDDS) in 1980's, they
attract the attention of researchers in order to confront the challenge of poor water-solubility …

Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product
development. The use of lipids in designing formulations provides an opportunity to …

Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical
development, which is linked to their limited oral bioavailability and therapeutic efficacy. To …

Aim The aim of this study was the formation and characterization of various ion pairs of
therapeutic peptides with different surfactants in order to reach a high payload in self …

Aim It was the aim of this study to evaluate the mucus permeating properties of self-
emulsifying drug delivery systems (SEDDS) exhibiting different size and zeta potential …

Human neurohormone vasopressin (AVP) is synthesized in overlap** regions in the
hypothalamus. It is mainly known for its vasoconstricting abilities, and it is responsible for the …

Mucus is a dynamic barrier which covers and protects the underlying mucosal epithelial
membrane against bacteria and foreign particles. This protection mechanism extends to …