Critical reanalysis of the mechanisms underlying the cardiorenal benefits of SGLT2 inhibitors and reaffirmation of the nutrient deprivation signaling/autophagy …

M Packer - Circulation, 2022 - ahajournals.org
SGLT2 (sodium-glucose cotransporter 2) inhibitors produce a distinctive pattern of benefits
on the evolution and progression of cardiomyopathy and nephropathy, which is …

A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging

AN Linders, IB Dias, T López Fernández, CG Tocchetti… - npj Aging, 2024 - nature.com
The population of cancer survivors is rapidly increasing due to improving healthcare.
However, cancer therapies often have long-term side effects. One example is cancer therapy …

Direct cardiac effects of SGLT2 inhibitors

S Chen, R Coronel, MW Hollmann, NC Weber… - Cardiovascular …, 2022 - Springer
Abstract Sodium-glucose-cotransporter 2 inhibitors (SGLT2is) demonstrate large
cardiovascular benefit in both diabetic and non-diabetic, acute and chronic heart failure …

[HTML][HTML] SGLT-2 inhibitors in cancer treatment—mechanisms of action and emerging new perspectives

M Dutka, R Bobiński, T Francuz, W Garczorz, K Zimmer… - Cancers, 2022 - mdpi.com
Simple Summary Despite significant advances in the treatment of cancer, it remains a major
cause of death worldwide and new treatment options are constantly being sought. An …

Canagliflozin mitigates ferroptosis and improves myocardial oxidative stress in mice with diabetic cardiomyopathy

S Du, H Shi, L **ong, P Wang, Y Shi - Frontiers in endocrinology, 2022 - frontiersin.org
Canagliflozin (Cana), an anti-diabetes drug belongs to sodium-glucose cotransporter 2
inhibitor, is gaining interest because of its extra cardiovascular benefits. Ferroptosis is a new …

Cardiotoxicity of anticancer drugs: molecular mechanisms and strategies for cardioprotection

MB Morelli, C Bongiovanni, S Da Pra… - Frontiers in …, 2022 - frontiersin.org
Chemotherapy and targeted therapies have significantly improved the prognosis of
oncology patients. However, these antineoplastic treatments may also induce adverse …

Associations between life's essential 8 and non-alcoholic fatty liver disease among US adults

L Wang, J Yi, X Guo, X Ren - Journal of Translational Medicine, 2022 - Springer
Background Nonalcoholic fatty liver disease (NAFLD) is closely associated with
Cardiovascular disease (CVD). We aim to examine the association of Life's Essential 8 …

Biomarkers for breast cancer immunotherapy: PD-L1, TILs, and beyond

A Rizzo, AD Ricci - Expert opinion on investigational drugs, 2022 - Taylor & Francis
ABSTRACT Introduction Immune checkpoint inhibitors (ICIs) have recently entered into the
therapeutic scenario of metastatic breast cancer. However, only a proportion of patients …

Sodium-glucose co-transporter-2 inhibitors and cardiac outcomes among patients treated with anthracyclines

CA Gongora, ZD Drobni… - Heart Failure, 2022 - jacc.org
Background Sodium-glucose co-transporter-2 (SGLT2) inhibitors improve outcomes among
patients with established heart failure. Despite supportive basic science studies, there are …

[HTML][HTML] Research progress of therapeutic drugs for doxorubicin-induced cardiomyopathy

Y Chen, S Shi, Y Dai - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Doxorubicin (DOX), as a kind of chemotherapy agent with remarkable therapeutic effect, can
be used to treat diverse malignant tumors clinically. Dose-dependent cardiotoxicity is the …