Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

XL Fan, Y Zhang, X Li, QL Fu - Cellular and molecular life sciences, 2020 - Springer
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …

An updated advance of autoantibodies in autoimmune diseases

ZX **ao, JS Miller, SG Zheng - Autoimmunity reviews, 2021 - Elsevier
Autoantibodies are abnormal antibodies which are generated by pathogenic B cells when
targeting an individual's own tissue. Autoantibodies have been identified as a symbol of …

[HTML][HTML] Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss

Y Nakao, T Fukuda, Q Zhang, T Sanui, T Shinjo, X Kou… - Acta biomaterialia, 2021 - Elsevier
Mesenchymal stem cell (MSC)–derived exosome plays a central role in the cell-free
therapeutics involving MSCs and the contents can be customized under disease-associated …

Mesenchymal stem cell–derived exosomes: a promising biological tool in nanomedicine

W Wei, Q Ao, X Wang, Y Cao, Y Liu… - Frontiers in …, 2021 - frontiersin.org
As nano-scale biological vesicles, extracellular vesicles (EVs)/exosomes, in particular,
exosomes derived from mesenchymal stem cells (MSC-exosomes), have been studied in …

Gingiva-derived mesenchymal stem cells: potential application in tissue engineering and regenerative medicine-a comprehensive review

D Kim, AE Lee, Q Xu, Q Zhang, AD Le - Frontiers in Immunology, 2021 - frontiersin.org
A unique subpopulation of mesenchymal stem cells (MSCs) has been isolated and
characterized from human gingival tissues (GMSCs). Similar to MSCs derived from other …

[HTML][HTML] Role and application of stem cells in dental regeneration: A comprehensive overview

A Soudi, M Yazdanian, R Ranjbar, H Tebyanian… - Excli Journal, 2021 - ncbi.nlm.nih.gov
Recently, a growing attention has been observed toward potential advantages of stem cell
(SC)-based therapies in regenerative treatments. Mesenchymal stem/stromal cells (MSCs) …

Human gingival tissue-derived MSC suppress osteoclastogenesis and bone erosion via CD39-adenosine signal pathway in autoimmune arthritis

Y Luo, W Wu, J Gu, X Zhang, J Dang, J Wang… - …, 2019 - thelancet.com
Background Bone destruction is one of many severe complications that occurs in patients
with rheumatoid arthritis (RA) and current therapies are unable to cure this manifestation …

Gingival mesenchymal stem cell‐derived exosomes are immunosuppressive in preventing collagen‐induced arthritis

X Tian, W Wei, Y Cao, T Ao, F Huang… - Journal of Cellular …, 2022 - Wiley Online Library
Due to the unsatisfied effects of clinical drugs used in rheumatoid arthritis (RA), investigators
shifted their focus on the biotherapy. Although human gingival mesenchymal stem cells …

Adipose-derived stem cell exosomes as a novel anti-inflammatory agent and the current therapeutic targets for rheumatoid arthritis

TH Chang, CS Wu, SH Chiou, CH Chang, HJ Liao - Biomedicines, 2022 - mdpi.com
Patients with rheumatoid arthritis (RA), a chronic inflammatory joint disorder, may not
respond adequately to current RA treatments. Mesenchymal stem cells (MSCs) elicit several …

Human gingiva-derived mesenchymal stem cells modulate monocytes/macrophages and alleviate atherosclerosis

X Zhang, F Huang, W Li, J Dang, J Yuan… - Frontiers in …, 2018 - frontiersin.org
Atherosclerosis is the major cause of cardiovascular diseases. Current evidences indicate
that inflammation is involved in the pathogenesis of atherosclerosis. Human gingiva-derived …