The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of
death in America. Advancing age is a major risk factor for CVD. Recent plateaus in CVD …

The benefits of exercise on the heart are well recognized, and clinical studies have
demonstrated that exercise is an intervention that can improve cardiac function in heart …

The blood–brain barrier (BBB) precisely controls brain microenvironment and neural activity
by regulating substance transport into and out of the brain. However, it severely hinders drug …

Mitochondrial dysfunction is one of the fundamental causes of ischemia reperfusion (I/R)
damage. I/R refers to the paradoxical progression of cellular dysfunction and death that …

RNA editing critically regulates neurodevelopment and normal neuronal function. The global
landscape of RNA editing was surveyed across 364 schizophrenia cases and 383 control …

Globally, migraine is a leading cause of disability with a huge impact on both the work and
private life of affected persons. To overcome the societal migraine burden, better treatment …

Kir6. 1 and SUR2 are subunits of ATP-sensitive potassium (KATP) channels expressed in a
wide range of tissues. Extensive study has implicated roles of these channel subunits in …

Hydrogen sulfide (H2S), a gas traditionally considered toxic, is now recognized as a vital
endogenous signaling molecule with a complex physiology. This comprehensive study …