The maturation of high-throughput short-read sequencing technology over the past two
decades has shaped the way genomes are studied. Recently, single-molecule, long-read …

Sequencing technology is the most commonly used technology in molecular biology
research and an essential pillar for the development and applications of molecular biology …

Nanopore sequencing depends on the FAST5 file format, which does not allow efficient
parallel analysis. Here we introduce SLOW5, an alternative format engineered for efficient …

Read map** is a fundamental step in many genomics applications. It is used to identify
potential matches and differences between fragments (called reads) of a sequenced …

In silico simulation of high-throughput sequencing data is a technique used widely in the
genomics field. However, there is currently a lack of effective tools for creating simulated …

Long-read sequencing is now routinely used at scale for genomics and transcriptomics
applications. Map** long reads or a draft genome assembly to a reference sequence is …

Background Third-generation nanopore sequencers offer selective sequencing or “Read
Until” that allows genomic reads to be analyzed in real time and abandoned halfway if not …

It has been over a decade since the first publication of a method dedicated entirely to
map** long-reads. The distinctive characteristics of long reads resulted in methods …

We now need more than ever to make genome analysis more intelligent. We need to read,
analyze, and interpret our genomes not only quickly, but also accurately and efficiently …

Motivation Nanopore sequencing is emerging as a key pillar in the genomic technology
landscape but computational constraints limiting its scalability remain to be overcome. The …