The role of CREBBP/EP300 and its therapeutic implications in hematological malignancies
Y Zhu, Z Wang, Y Li, H Peng, J Liu, J Zhang, X ** acute leukemia compared to the overall population. Many studies investigating …
Chromatin accessibility maps provide evidence of multilineage gene priming in hematopoietic stem cells
EW Martin, J Krietsch, RE Reggiardo, R Sousae… - Epigenetics & …, 2021 - Springer
Hematopoietic stem cells (HSCs) have the capacity to differentiate into vastly different types
of mature blood cells. The epigenetic mechanisms regulating the multilineage ability, or …
of mature blood cells. The epigenetic mechanisms regulating the multilineage ability, or …
Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis
Z Chen, D Huo, L Li, Z Liu, Z Li, S Xu… - Journal of Experimental …, 2021 - rupress.org
The oncogene DEK is found fused with the NUP214 gene creating oncoprotein DEK-
NUP214 that induces acute myeloid leukemia (AML) in patients, and secreted DEK protein …
NUP214 that induces acute myeloid leukemia (AML) in patients, and secreted DEK protein …
HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort
The genetic basis of the predisposition for Down Syndrome (DS) patients to develop
cytokine receptor-like factor 2 rearranged (CRLF2r) acute lymphoblastic leukemia (ALL) is …
cytokine receptor-like factor 2 rearranged (CRLF2r) acute lymphoblastic leukemia (ALL) is …