Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …

Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Drinking water contamination with heavy metals, particularly lead, is a persistent problem
worldwide with grave public health consequences. Existing purification methods often …

The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …

Machine learning methods have been applied to many data sets in pharmaceutical research
for several decades. The relative ease and availability of fingerprint type molecular …

Reducing the burden of infectious diseases that affect people in the develo** world
requires sustained collaborative drug discovery efforts. The quality of the chemical starting …

Abstract ChEMBL is an Open Data database containing binding, functional and ADMET
information for a large number of drug-like bioactive compounds. These data are manually …

Despite substantial scientific progress over the past two decades, malaria remains a
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …

Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan,
claims the lives of nearly a million children each year in Africa alone and is a top public …

Recent reports of increased tolerance to artemisinin derivatives—the most recently adopted
class of antimalarials—have prompted a need for new treatments. The spirotetrahydro-β …