Endothelial cells (ECs) constitute the inner lining of vascular beds in mammals and are
crucial for homeostatic regulation of blood vessel physiology, but also play a key role in …

Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …

The estrogen receptor (ER) designated ERα has actions in many cell and tissue types that
impact glucose homeostasis. It is unknown if these include mechanisms in endothelial cells …

Background: Hydrogen sulfide is a critical endogenous signaling molecule that exerts
protective effects in the setting of heart failure. Cystathionine γ-lyase (CSE), 1 of 3 hydrogen …

Brain vascular integrity is critical for brain health, and its disruption is implicated in many
brain pathologies, including psychiatric disorders. Brain-vascular barriers are a complex …

Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary
arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism …

Ischemic stroke-induced mitochondrial dysfunction in the blood-brain barrier-forming brain
endothelial cells (BECs) results in long-term neurological dysfunction post-stroke. We …

Retinoids are potent transcriptional regulators that act in regulating cell proliferation,
differentiation, and other cellular processes. We carried out studies in male mice to establish …

Cell isolation protocols from brain tissue include prolonged ex vivo processing durations,
rendering them suboptimal for transcriptomic studies. Particularly for microglia and vascular …

The identification and role of endothelial progenitor cells in pulmonary arterial hypertension
(PAH) remain controversial. Single-cell omics analysis can shed light on endothelial …