Background The proliferation of inhaler devices has resulted in a confusing number of
choices for clinicians who are selecting a delivery device for aerosol therapy. There are …

Successful aerosol therapy generally depends on the small percentage (typically 10
percent) of the drug dose delivered to the lungs from metered-dose inhalers (MDIs) …

This thoroughly revised and expanded reference provides authoritative discussions on the
physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors …

The effect on aerosol deposition from a pressurised metered dose inhaler of a 750 cm3
spacer device with a one way inhalation valve (Nebuhaler, Astra Pharmaceuticals) was …

The purpose of this study was to compare deposition of aerosol to the lung from a metered-
dose inhaler (MOl) and aerosol holding chamber and from a jet nebulizer in …

Inhalation of medication is the preferred method for treating reversible airway obstruction;
however, difficulties in the use of pressurized canisters frequently lead to suboptimal results …

Budesonide, a topically active corticosteroid, was administered in doses of 400 and 1,600
μg/day to 35 asthmatic adults, using a standard inhalation device or a tube or cone spacer …

Spacers and valved holding chambers (VHCs) are pressurized metered dose inhaler (pMDI)
accessory devices, designed to overcome problems that patients commonly experience …

Add-on devices for pressurised metered dose inhalers (MDIs) improve" targeting" of drug to
the lungs and can correct for hand–breath dyscoordination. Measurements of drug delivery …

Metered dose inhalers (MDIs) which have a valve holding chamber plus a mouthpiece or
mask have, in recent years, markedly improved the ease, speed and reliability of aerosol …