Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Conquering the hypoxia limitation for photodynamic therapy

Y Wan, LH Fu, C Li, J Lin, P Huang - Advanced Materials, 2021 - Wiley Online Library
Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its
high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However …

Clinical development of metal complexes as photosensitizers for photodynamic therapy of cancer

J Karges - Angewandte chemie international edition, 2022 - Wiley Online Library
Cancer has emerged over the last decades as one of the deadliest diseases in the world.
Among the most commonly used techniques (ie surgery, immunotherapy, radiotherapy or …

Cancer therapeutics based on diverse energy sources

S Son, J Kim, J Kim, B Kim, J Lee, Y Kim, M Li… - Chemical Society …, 2022 - pubs.rsc.org
Light-based phototherapy has been developed for cancer treatment owing to its non-
invasiveness and spatiotemporal control. Despite the unique merits of phototherapy, one …

Innovative strategies for hypoxic‐tumor photodynamic therapy

X Li, N Kwon, T Guo, Z Liu… - Angewandte Chemie …, 2018 - Wiley Online Library
Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback
associated with its oxygen‐dependent nature, which limits its effective use against hypoxic …

Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics

W Tang, W Fan, J Lau, L Deng, Z Shen… - Chemical Society …, 2019 - pubs.rsc.org
Brain cancer, especially the most common type of glioblastoma, is highly invasive and
known as one of the most devastating and deadly neoplasms. Despite surgical and medical …

Smart and bioinspired systems for overcoming biological barriers and enhancing disease theranostics

X Li, Y Gao, H Li, JP Majoral, X Shi, A Pich - Progress in Materials Science, 2023 - Elsevier
Nanomedicine has emerged as a promising mean to improve theranostic efficacy and
reduce side effects. Currently, only very small percentage of injected dose reaches the solid …

Near-infrared light-initiated molecular superoxide radical generator: rejuvenating photodynamic therapy against hypoxic tumors

M Li, J **a, R Tian, J Wang, J Fan, J Du… - Journal of the …, 2018 - ACS Publications
Hypoxia, a quite universal feature in most solid tumors, has been considered as the
“Achilles' heel” of traditional photodynamic therapy (PDT) and substantially impairs the …

Nanozyme decorated metal–organic frameworks for enhanced photodynamic therapy

Y Zhang, F Wang, C Liu, Z Wang, LH Kang, Y Huang… - ACS …, 2018 - ACS Publications
Metal–organic frameworks (MOFs) have been used for photodynamic therapy (PDT) of
cancers by integrating photosensitizers, which cause cytotoxic effects on cancer cells by …

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Z Zhou, J Song, L Nie, X Chen - Chemical society reviews, 2016 - pubs.rsc.org
The reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the
efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of …