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Peptides of a feather: How computation Is taking peptide therapeutics under its wing
Leveraging computation in the development of peptide therapeutics has garnered
increasing recognition as a valuable tool to generate novel therapeutics for disease-related …
increasing recognition as a valuable tool to generate novel therapeutics for disease-related …
Platelet-type von Willebrand disease: complex pathophysiology and insights on novel therapeutic and diagnostic strategies
von Willebrand disease (VWD) is the most common well-studied genetic bleeding disorder
worldwide. Much less is known about platelet-type VWD (PT-VWD), a rare platelet function …
worldwide. Much less is known about platelet-type VWD (PT-VWD), a rare platelet function …
Zika virus envelope–heat shock protein A5 (GRP78) binding site prediction
Recent studies reported the association of the Zika virus (ZIKV) with a stress response
receptor on the host cell membrane that facilitates viral entry. This host receptor was the heat …
receptor on the host cell membrane that facilitates viral entry. This host receptor was the heat …
Designing a novel multiepitope peptide vaccine against melanoma using immunoinformatics approach
Malignant melanoma is the most aggressive and life-threaten skin cancer. Nowadays, the
prevention and treatment of melanoma are challenging areas for researchers and …
prevention and treatment of melanoma are challenging areas for researchers and …
[HTML][HTML] Determining human-coronavirus protein-protein interaction using machine intelligence
Abstract The Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) virus
spread the novel CoronaVirus− 19 (nCoV-19) pandemic, resulting in millions of fatalities …
spread the novel CoronaVirus− 19 (nCoV-19) pandemic, resulting in millions of fatalities …
PIPE4: Fast PPI predictor for comprehensive inter-and cross-species interactomes
The need for larger-scale and increasingly complex protein-protein interaction (PPI)
prediction tasks demands that state-of-the-art predictors be highly efficient and adapted to …
prediction tasks demands that state-of-the-art predictors be highly efficient and adapted to …
Reciprocal perspective for improved protein-protein interaction prediction
All protein-protein interaction (PPI) predictors require the determination of an operational
decision threshold when differentiating positive PPIs from negatives. Historically, a single …
decision threshold when differentiating positive PPIs from negatives. Historically, a single …
Investigational drugs for the treatment of Zika virus infection: a preclinical and clinical update
Y Han, T Mesplède - Expert Opinion on Investigational Drugs, 2018 - Taylor & Francis
ABSTRACT Introduction: The Zika virus (ZIKV) infection results in severe neurological
complications and has emerged as a threat to public health worldwide. No drugs or vaccines …
complications and has emerged as a threat to public health worldwide. No drugs or vaccines …
In silico identification of drug target pathways in breast cancer subtypes using pathway cross-talk inhibition
Background Despite great development in genome and proteome high-throughput methods,
treatment failure is a critical point in the management of most solid cancers, including breast …
treatment failure is a critical point in the management of most solid cancers, including breast …
Computer-assisted and data driven approaches for surveillance, drug discovery, and vaccine design for the Zika virus
Human life has been at the edge of catastrophe for millennia due diseases which emerge
and reemerge at random. The recent outbreak of the Zika virus (ZIKV) is one such menace …
and reemerge at random. The recent outbreak of the Zika virus (ZIKV) is one such menace …