Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …

The genus Mycobacterium includes a variety of species with differing phenotypic properties,
including growth rate, pathogenicity and environment-and host-specificity. Although many …

Although the bovine tuberculosis (TB) agent, Mycobacterium bovis, may infect humans and
cause disease, long-term epidemiological data indicate that humans represent a spill-over …

Bacterial secretion systems were initially studied in the Gram‐negative bacterium
Escherichia coli K‐12. When researchers started to explore protein secretion in different …

Phase variation induced by insertions and deletions (INDELs) in genomic homopolymeric
tracts (HT) can silence and regulate genes in pathogenic bacteria, but this process is not …

The ESX-1 secretion system exports the immunomodulatory protein ESAT-6 and other
proteins important in the pathogenesis of Mycobacterium tuberculosis. Components and …

Pathogenic mycobacteria cause chronic and acute diseases ranging from human
tuberculosis (TB) to nontubercular infections. Mycobacterium tuberculosis causes both acute …

Mycobacterium tuberculosis causes pulmonary tuberculosis (TB) and claims~ 1.8 million
human lives per annum. Host nitric oxide (NO) is important in controlling TB infection. M …

Bacterial secretion systems are sophisticated molecular machines that fulfil a wide range of
important functions, which reach from export/secretion of essential proteins or virulence …

Attenuation of Mycobacterium bovis BCG strain is related to the loss of the RD1-encoded
ESX-1 secretion system. The ESX-1 system secretes virulence factor ESAT-6 that plays a …