The process of poly (ADP-ribosyl) ation and the major enzyme that catalyses this reaction,
poly (ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago. Since …

Vascular calcification (VC), which is categorized by intimal and medial calcification,
depending on the site (s) involved within the vessel, is closely related to cardiovascular …

Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

Cardiovascular disease is the most common cause of death worldwide, especially beyond
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …

Solid-state NMR spectroscopy (ssNMR) with magic-angle spinning (MAS) enables the
investigation of biological systems within their native context, such as lipid membranes, viral …

Oxidative stress is an imbalance between pro-and antioxidants that adversely influences the
organism in various mechanisms and on many levels. Oxidative damage occurring …

Ketocholesterol (7KC) is a toxic oxysterol that is associated with many diseases and
disabilities of aging, as well as several orphan diseases. 7KC is the most common product of …

Abstract Two decades ago, Kidney Disease: Improving Global Outcomes coined the term
chronic kidney disease–mineral and bone disorder (CKD–MBD) to describe the syndrome of …

Over 200 million individuals worldwide are estimated to have peripheral artery disease
(PAD). Although the term peripheral can refer to any outer branch of the vasculature, the …

Chronic kidney disease (CKD) is a clinical model of premature ageing characterized by
cardiovascular disease, persistent uraemic inflammation, osteoporosis muscle wasting and …