The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Despite efficient combination of the antiretroviral therapy (cART), which significantly
decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been …

The development of persistent cellular reservoirs of latent human immunodeficiency virus
(HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti …

Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …

The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently
the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV …

Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …

Co-infection with Mycobacterium tuberculosis is the leading cause of death in individuals
infected with HIV-1. It has long been known that HIV-1 infection alters the course of M …

Human immunodeficiency virus type 1 (HIV-1) eradication is prevented by the establishment
on infection of cellular HIV-1 reservoirs that are not fully characterized, especially in genital …

In people living with HIV (PLWH) who are failing or unable to access combination
antiretroviral therapy (cART), monocytes and macrophages are important drivers of …

Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from
infected cells and tissues. Here, sequential long-acting slow-effective release antiviral …