Applications of immunomodulatory immune synergies to adjuvant discovery and vaccine development
Pathogens comprise a diverse set of immunostimulatory molecules that activate the innate
immune system during infection. The immune system recognizes distinct combinations of …
immune system during infection. The immune system recognizes distinct combinations of …
[HTML][HTML] Inflammasomes as targets for adjuvants
Inflammasomes are an essential part of the innate immune system. They are necessary for
the development of a healthy immune response against infectious diseases. Inflammasome …
the development of a healthy immune response against infectious diseases. Inflammasome …
[HTML][HTML] Empagliflozin alleviates the development of autoimmune myocarditis via inhibiting NF-κB-dependent cardiomyocyte pyroptosis
C Lv, C Hu, C Zhu, X Wan, C Chen, X Ji, Y Qin… - Biomedicine & …, 2024 - Elsevier
Autoimmune myocarditis, which falls within the broad spectrum of myocarditis, is
characterized by an excessive inflammatory response in the heart, and can progress into …
characterized by an excessive inflammatory response in the heart, and can progress into …
In silico analysis and in vivo assessment of a novel epitope-based vaccine candidate against uropathogenic Escherichia coli
Uropathogenic Escherichia coli (UPEC) are common pathogens in urinary tract infections
(UTIs), which show resistance to antibiotics. Therefore, there is a need for a vaccine to …
(UTIs), which show resistance to antibiotics. Therefore, there is a need for a vaccine to …
Tricarbocyanine N-triazoles: the scaffold-of-choice for long-term near-infrared imaging of immune cells in vivo
Herein tricarbocyanine N-triazoles are first described as a rationally-designed near-infrared
(NIR) structure overcoming the brightness and photostability limitations of tricarbocyanines …
(NIR) structure overcoming the brightness and photostability limitations of tricarbocyanines …
Non-cytotoxic cardiac innate lymphoid cells are a resident and quiescent type 2-commited population
Innate lymphoid cells (ILC) are a subset of leukocytes with lymphoid properties that lack
antigen specific receptors. They can be stimulated by and exert their effect via specific …
antigen specific receptors. They can be stimulated by and exert their effect via specific …
A juvenile mouse model of anti-N-methyl-D-aspartate receptor encephalitis by active immunization
S He, C Sun, Q Zhu, L Li, J Huang, G Wu… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a common
autoimmune encephalitis, and it is associated with psychosis, dyskinesia, and seizures. Anti …
autoimmune encephalitis, and it is associated with psychosis, dyskinesia, and seizures. Anti …
PD-1 inhibitor induces myocarditis by reducing regulatory T cells, activating inflammatory responses, promoting myocardial apoptosis and autophagy
Y Liu, Y Song, X Liu, S Xu, C Kong, L Chen, H Qian… - Cytokine, 2022 - Elsevier
The present study aimed to explore the pathogenesis of autoimmune myocarditis induced by
PD-1 inhibitors and their potential therapeutic targets. Mouse models of autoimmune …
PD-1 inhibitors and their potential therapeutic targets. Mouse models of autoimmune …
Freund's adjuvant is a classic of vaccine adjuvants and the basis of experimental immunology
Background. The invention of vaccines is rightfully considered one of the triumphs of
medical research and one of the most remarkable achievements in public health in the …
medical research and one of the most remarkable achievements in public health in the …
Tridecylcyclohexane in incomplete Freund's adjuvant is a critical component in inducing experimental autoimmune diseases
Incomplete Freund's adjuvant (IFA) has been used for many years to induce autoimmune
diseases in animal models, including experimental autoimmune encephalitis and collagen …
diseases in animal models, including experimental autoimmune encephalitis and collagen …