Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

The complement system is a recognized pillar of host defence against infection and noxious
self-derived antigens. Complement is traditionally known as a serum-effective system …

The complement system is recognised as a protector against blood-borne pathogens and a
controller of immune system and tissue homoeostasis. However, dysregulated complement …

The omics era made possible the quest for efficient markers for cancer progression and
revealed that macrophage populations are much more complex than just the M1/M2 …

The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …

The crosstalk among the complement system, immune cells, and mediators of inflammation
provides an efficient mechanism to protect the organism against infections and support the …

Systemic candidiasis is a common, high-mortality, nosocomial fungal infection.
Unexpectedly, it has emerged as a complication of anti-complement C5-targeted …

Complement factor H (CFH) negatively regulates consumption of complement component 3
(C3), thereby restricting complement activation. Genetic variants in CFH predispose to …

C3 is the central effector molecule of the complement system, mediating its multiple
functions through different binding sites and their corresponding receptors. We will introduce …

As one of the cornerstones of innate immunity, the complement system has long been
implicated in the pathogenesis of atherosclerosis. Growing evidence demonstrates the …