Chemotherapeutic drugs target a physiological differentiating feature of cancer cells as they
tend to actively proliferate more than normal cells. They have well-known side-effects …

Resistance to chemotherapeutic drugs is the major hindrance in the successful cancer
therapy. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of …

The endoplasmic reticulum (ER) stress response constitutes a cellular process that can be
triggered by a great variety of conditions that cause imbalances in intracellular homeostasis …

Metabolic stress occurs frequently in tumors and in normal tissues undergoing transient
ischemia. Nutrient deprivation triggers, among many potential cell death-inducing pathways …

Direct pulmonary delivery of anti-cancer agents is viewed as an effective way of treating lung
cancer. Here, we fabricated inhalable nanoparticles made of human serum albumin (HSA) …

Inhalable highly porous large PLGA microparticles with incorporated doxorubicin and
surface-attached with TRAIL (TRAIL/Dox PLGA MP) were fabricated using aw/o/w double …

We previously reported that cells harboring the hepatitis C virus (HCV) RNA replicon as well
as those expressing HCV NS3/4A exhibited increased sensitivity to suboptimal doses of …

Tumor necrosis-factor related apoptosis-inducing ligand, also known as TRAIL or APO2L
(Apo-2 ligand), is a cytokine of the TNF superfamily acknowledged for its ability to trigger …

Tunicamycin (TM) inhibits eukaryotic asparagine-linked glycosylation, protein palmitoylation,
ganglioside production, proteoglycan synthesis, 3-hydroxy-3-methylglutaryl coenzyme-A …

The pathways of reactive oxygen species (ROS)-mediated apoptosis induction, of Bax
activation and the sensitization of tumor cells for TRAIL (TNF-related apoptosis-inducing …