Redox signaling by reactive electrophiles and oxidants
The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
Manipulation and motion of organelles and single molecules in living cells
K Norregaard, R Metzler, CM Ritter… - Chemical …, 2017 - ACS Publications
The biomolecule is among the most important building blocks of biological systems, and a
full understanding of its function forms the scaffold for describing the mechanisms of higher …
full understanding of its function forms the scaffold for describing the mechanisms of higher …
Brownian yet non-Gaussian diffusion: from superstatistics to subordination of diffusing diffusivities
A growing number of biological, soft, and active matter systems are observed to exhibit
normal diffusive dynamics with a linear growth of the mean-squared displacement, yet with a …
normal diffusive dynamics with a linear growth of the mean-squared displacement, yet with a …
Protein crowding in lipid bilayers gives rise to non-Gaussian anomalous lateral diffusion of phospholipids and proteins
Biomembranes are exceptionally crowded with proteins with typical protein-to-lipid ratios
being around 1∶ 50− 1∶ 100. Protein crowding has a decisive role in lateral membrane …
being around 1∶ 50− 1∶ 100. Protein crowding has a decisive role in lateral membrane …
The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery
Lipofectamine reagents are widely accepted as “gold-standard” for the safe delivery of
exogenous DNA or RNA into cells. Despite this, a satisfactory mechanism-based …
exogenous DNA or RNA into cells. Despite this, a satisfactory mechanism-based …
Inferring entropy production from short experiments
We provide a strategy for the exact inference of the average as well as the fluctuations of the
entropy production in nonequilibrium systems in the steady state, from the measurements of …
entropy production in nonequilibrium systems in the steady state, from the measurements of …
Identifiability analysis for stochastic differential equation models in systems biology
Mathematical models are routinely calibrated to experimental data, with goals ranging from
building predictive models to quantifying parameters that cannot be measured. Whether or …
building predictive models to quantifying parameters that cannot be measured. Whether or …
Microorganisms maintain crowding homeostasis
J Van Den Berg, AJ Boersma, B Poolman - Nature Reviews …, 2017 - nature.com
Macromolecular crowding affects the mobility of biomolecules, protein folding and stability,
and the association of macromolecules with each other. Local differences in crowding that …
and the association of macromolecules with each other. Local differences in crowding that …
Towards a robust criterion of anomalous diffusion
Anomalous-diffusion, the departure of the spreading dynamics of diffusing particles from the
traditional law of Brownian-motion, is a signature feature of a large number of complex soft …
traditional law of Brownian-motion, is a signature feature of a large number of complex soft …
Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells
The diffusivity of macromolecules in the cytoplasm of eukaryotic cells varies over orders of
magnitude and dictates the kinetics of cellular processes. However, a general description …
magnitude and dictates the kinetics of cellular processes. However, a general description …