Adult hippocampal neurogenesis generates functional neurons from neural progenitor cells
in the hippocampal dentate gyrus (DG) to complement and repair neurons and neural …

Chronic stress is a major risk factor for various psychiatric diseases, including depression; it
triggers various cellular and structural changes, resulting in the alteration of neurocircuitry …

Maternal infection during pregnancy and childhood social trauma have been associated
with neurodevelopmental and affective disorders, such as schizophrenia, autism spectrum …

Abstract Background 17β-Estradiol (E2) is generally considered neuroprotective in humans.
However, the current clinical use of estrogen replacement therapy (ERT) is based on the …

Stroke is one of the most common cerebrovascular diseases, which is the cause of long-term
mental illness and physical disability, Post-stroke depression (PSD) is the most common …

Negative experiences during adolescence, such as social isolation (SI), bullying, and abuse,
increase the risk of psychiatric diseases in adulthood. However, the pathogenesis of …

Immune cells are the housekeepers of the human body. They protect the body from
pathogens, cellular damage, and foreign matter. Proper activation of immune cells is of great …

Background The endocannabinoid system plays a crucial role in regulating mood, but the
specific involvement of cannabinoid receptor type 2 (CB2R) in depression remains poorly …

Background Epilepsy, a neurological disorder characterized by recurrent abnormal neuronal
discharges, leading to brain dysfunction and imposing significant psychological and …

Background Both functional brain imaging studies and autopsy reports have indicated the
presence of synaptic loss in the brains of depressed patients. The activated microglia may …