The microbiota-gut-brain axis: from motility to mood
The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and
extrinsic factors influence signaling along this axis, modulating the function of both the …
extrinsic factors influence signaling along this axis, modulating the function of both the …
Gut bacteria and neurotransmitters
LMT Dicks - Microorganisms, 2022 - mdpi.com
Gut bacteria play an important role in the digestion of food, immune activation, and
regulation of entero-endocrine signaling pathways, but also communicate with the central …
regulation of entero-endocrine signaling pathways, but also communicate with the central …
[HTML][HTML] Single-cell analysis of Crohn's disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy
Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset of
patients. Here, we applied single-cell technologies to iCD lesions to address whether …
patients. Here, we applied single-cell technologies to iCD lesions to address whether …
Enteric glial biology, intercellular signalling and roles in gastrointestinal disease
L Seguella, BD Gulbransen - Nature reviews Gastroenterology & …, 2021 - nature.com
One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …
many functions normally attributed to enteric neurons involve interactions with enteric glial …
Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks
F De Vadder, E Grasset… - Proceedings of the …, 2018 - National Acad Sciences
The enteric nervous system (ENS) is crucial for essential gastrointestinal physiologic
functions such as motility, fluid secretion, and blood flow. The gut is colonized by trillions of …
functions such as motility, fluid secretion, and blood flow. The gut is colonized by trillions of …
Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
Group 2 innate lymphoid cells (ILC2s) regulate inflammation, tissue repair and metabolic
homeostasis, and are activated by host-derived cytokines and alarmins. Discrete subsets of …
homeostasis, and are activated by host-derived cytokines and alarmins. Discrete subsets of …
Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia
FA Vicentini, CM Keenan, LE Wallace, C Woods… - Microbiome, 2021 - Springer
Background The intestinal microbiota plays an important role in regulating gastrointestinal
(GI) physiology in part through interactions with the enteric nervous system (ENS) …
(GI) physiology in part through interactions with the enteric nervous system (ENS) …
Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury
M Hanscom, DJ Loane… - The Journal of Clinical …, 2021 - Am Soc Clin Investig
Traumatic brain injury (TBI) is a chronic and progressive disease, and management requires
an understanding of both the primary neurological injury and the secondary sequelae that …
an understanding of both the primary neurological injury and the secondary sequelae that …
Disorders of the enteric nervous system—a holistic view
The enteric nervous system (ENS) is the largest division of the peripheral nervous system
and closely resembles components and functions of the central nervous system. Although …
and closely resembles components and functions of the central nervous system. Although …
The physiology of enteric glia
J Gonzales, BD Gulbransen - Annual Review of Physiology, 2024 - annualreviews.org
Enteric glia are the partners of neurons in the enteric nervous system throughout the
gastrointestinal tract. Roles fulfilled by enteric glia are diverse and contribute to maintaining …
gastrointestinal tract. Roles fulfilled by enteric glia are diverse and contribute to maintaining …