The calyx of Held is an axosomatic terminal in the auditory brainstem that has attracted
anatomists because of its giant size and physiologists because of its accessibility to patch …

Hyperbilirubinemia (HB) is a key risk factor for hearing loss in neonates, particularly
premature infants. Here, we report that bilirubin (BIL)-dependent cell death in the auditory …

Excitatory glutamatergic neurons are part of most of the neuronal circuits in the mammalian
nervous system. We have used BAC-technology to generate a BAC-Vglut2:: Cre mouse line …

Principal cells of the medial nucleus of the trapezoid body (MNTB) receive their excitatory
input through large somatic terminals, the calyces of Held, which arise from axons of …

Neuronal networks within the spinal cord, collectively known as the central pattern generator
(CPG), coordinate rhythmic movements underlying locomotion. The transcription factor …

In neurons of the medial superior olive (MSO), voltage-gated ion channels control the
submillisecond time resolution of binaural coincidence detection, but little is known about …

Bushy cells in the ventral cochlear nucleus convey firing of auditory nerve fibers to neurons
in the superior olivary complex that compare the timing and intensity of sounds at the two …

Synaptic transmission at the inner hair cell (IHC) afferent synapse, the first synapse in the
auditory pathway, is specialized for rapid and reliable signaling. Here we investigated the …

In sensory circuits of the brain, developmental changes in the expression and modulation of
voltage-gated ion channels are a common occurrence, but such changes are often difficult to …

Optogenetics is revolutionizing Neuroscience, but an often neglected effect of light
stimulation of the brain is the generation of heat. In extreme cases, light-generated heat kills …