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The multiplex model of the genetics of Alzheimer's disease
Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
[HTML][HTML] The emerging role of cell-free DNA as a molecular marker for cancer management
An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …
[HTML][HTML] Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration
Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark
of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to …
of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to …
Human glioblastoma arises from subventricular zone cells with low-level driver mutations
Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …
The role of adult hippocampal neurogenesis in brain health and disease
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …
[HTML][HTML] Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders
Studies of the genetics of psychiatric disorders have become one of the most exciting and
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …
Clonal hematopoiesis and evolution to hematopoietic malignancies
Clonal hematopoiesis (CH) broadly describes the expansion of a clonal population of blood
cells with one or more somatic mutations. Individuals with CH are at greater risk for …
cells with one or more somatic mutations. Individuals with CH are at greater risk for …
Genetic insights into the neurodevelopmental origins of schizophrenia
Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …
neurobiological investigation. Although the underlying causal mechanisms remain …
Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy
Cortical malformations such as focal cortical dysplasia type II (FCDII) are associated with
pediatric drug-resistant epilepsy that necessitates neurosurgery. FCDII results from somatic …
pediatric drug-resistant epilepsy that necessitates neurosurgery. FCDII results from somatic …
Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease
Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …
requirements, elevated transcriptional activity, and long lifespan. While newer research has …