Spike-timing-dependent synaptic plasticity (STDP) is a leading cellular model for behavioral
learning and memory with rich computational properties. However, the relationship between …

Sleep is universal, tightly regulated, and many cognitive functions are impaired if we do not
sleep. But why? Why do our brains need to disconnect from the environment for hours every …

Activity-dependent synaptic plasticity is critical for cortical circuit refinement. The synaptic
homeostasis hypothesis suggests that synaptic connections are strengthened during wake …

Decades of neurobehavioral research has linked sleep-associated rhythms in various brain
areas to improvements in cognitive performance. However, it remains unclear what synaptic …

Sleep shapes cortical network activity, fostering global homeostatic downregulation of
excitability while maintaining or even upregulating excitability in selected networks in a …

Sleep can benefit memory consolidation. The characterization of brain regions underlying
memory consolidation during sleep, as well as their temporal interplay, reflected by specific …

Alternations of up and down can be seen across many different levels during sleep. Neural
firing-rates, synaptic markers, molecular pathways, and gene expression all show differential …

Neurons fire at highly variable intrinsic rates and recent evidence suggests that low-and
high-firing rate neurons display different plasticity and dynamics. Furthermore, recent …

Cortical computations emerge from the dynamics of neurons embedded in complex cortical
circuits. Within these circuits, neuronal ensembles, which represent subnetworks with …

Evidence links neuroinflammation to Alzheimer's disease (AD); however, its exact
contribution to the onset and progression of the disease is poorly understood. Symptoms of …