Resistance to chemotherapy and molecularly targeted therapies is a major problem facing
current cancer research. The mechanisms of resistance to'classical'cytotoxic …

Resistance to apoptosis is closely linked to tumorigenesis, as it enables malignant cells to
expand even in a stressful environment. Cells resistant to apoptosis are also assumed to be …

Chemotherapeutic drugs target a physiological differentiating feature of cancer cells as they
tend to actively proliferate more than normal cells. They have well-known side-effects …

Resistance to chemotherapy is a major obstacle in the treatment of cancer. Despite the
advent of new chemotherapies and molecular-targeted therapies, approximately 90% of …

Background: Recombinant tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)
induces tumour-selective apoptosis in various pre-clinical models by binding its specific …

Cellular FLICE (FADD-like IL-1beta-converting enzyme)-inhibitory protein (c-FLIP) is a major
resistance factor and critical anti-apoptotic regulator that inhibits tumor necrosis factor-alpha …

Cellular FLICE-inhibitory protein (c-FLIP) is a catalytically inactive procaspase-8/10
homologue that associates with the signalling complex downstream of death-receptors …

Cellular FLICE-like inhibitory protein (c-FLIP) has been identified as a protease-dead,
procaspase-8-like regulator of death ligand-induced apoptosis, based on observations that c …

Oncogenic transformation leads to changes in glutamine metabolism that make transformed
cells highly dependent on glutamine for anabolic growth and survival. Herein, we …

Deregulation of apoptosis is a hallmark of human cancer and contributes to therapeutic
resistance. Recent advances in cancer genomics have revealed a myriad of alterations in …