A diverse array of sex determination (SD) mechanisms, encompassing environmental to
genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD …

BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …

Die fortgesetzte Suche nach dem einzelnen ‚geschlechtsdeterminierenden Gen ': SRY als
TDF? 250 Downstream von SRY–weitere Gene, die hierarchisch unterhalb von SRY als an …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

The liver and exocrine pancreas share a common structure, with functioning units (hepatic
plates and pancreatic acini) connected to the ductal tree. Here we show that Sox9 is …

Sex in mammals is determined in the fetal gonad by the presence or absence of the Y
chromosome gene Sry, which controls whether bipotential precursor cells differentiate into …

Cell fate decisions require appropriate regulation of key genes. Sox9, a direct target of SRY,
is pivotal in mammalian sex determination. In vivo high-throughput chromatin accessibility …

Development of testes in the mammalian embryo requires the formation and assembly of
several cell types that allow these organs to achieve their roles in male reproduction and …

The mammalian Y chromosome acts as a dominant male determinant as a result of the
action of a single gene, Sry, whose role in sex determination is to initiate testis rather than …

The transcription factor SOX9 is essential for the development of multiple organs including
bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human …