Hepatotoxic microcystins (MCs) are the most widespread class of cyanotoxins and the one
that has most often been implicated in cyanobacterial toxicosis. One of the main challenges …

Microtubule associated protein tau is a phosphoprotein which potentially has 80
serine/threonine and 5 tyrosine phosphorylation sites. Normal brain tau contains 2-3 moles …

Protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases,
minimally containing a well conserved catalytic subunit, the activity of which is highly …

The phosphorylation state of any protein represents a balance of the actions of specific
protein kinases and protein phosphatases. Many protein phosphatases are highly enriched …

Phosphorylation and dephosphorylation of a protein often serve as an “on-and-off” switch in
the regulation of cellular activities. Recent studies demonstrate the involvement of protein …

This review deals with the influence of serine/threonine-specific protein phosphatases on
the function of ion channels in the plasma membrane of excitable tissues. Particular focus is …

Ionizing radiation induces autophosphorylation of the ataxia‐telangiectasia mutated (ATM)
protein kinase on serine 1981; however, the precise mechanisms that regulate ATM …

Reversible phosphorylation is a key mechanism for regulating the biological activity of many
human proteins that affect a diverse array of cellular processes, including protein-protein …

Publisher Summary This chapter discusses some general information about cyclic
nucleotide phosphodiesterases (PDEs). It also discusses the PDE3 gene family …

▪ Abstract The Drosophila phototransduction cascade has emerged as an attractive
paradigm for understanding the molecular mechanisms underlying visual transduction, as …