The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It is a
highly conserved evolutionary pathway of signal transmission from the cell membrane to the …

The Hedgehog (HH) signaling pathway was discovered originally as a key pathway in
embryonic patterning and development. Since its discovery, it has become increasingly …

Developmental signals of the Hedgehog (Hh) and Wnt families are transduced across the
membrane by Frizzled-class G-protein-coupled receptors (GPCRs) composed of both a …

Signaling pathways that mediate cell-cell communication are essential for collective cell
behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and …

The Hedgehog (Hh) pathway is a signaling cascade that plays a crucial role in many
fundamental processes, including embryonic development and tissue homeostasis …

The Smoothened receptor (SMO) mediates signal transduction in the hedgehog pathway,
which is implicated in normal development and carcinogenesis. SMO antagonists can …

Smoothened (SMO), a class Frizzled G protein-coupled receptor (class F GPCR), transduces
the Hedgehog signal across the cell membrane. Sterols can bind to its extracellular cysteine …

Hedgehog (Hh) is first described as a genetic mutation that has “spiked” phenotype in the
cuticles of Drosophila in later 1970s. Since then, Hh signaling has been implicated in …

Cell differentiation and proliferation require Hedgehog (HH) signaling and aberrant HH
signaling causes birth defects or cancers. In this signaling pathway, the N-terminally …

Wnt signalling regulates multiple processes including angiogenesis, inflammation, and
tumorigenesis. Norrin (Norrie Disease Protein) is a cystine-knot like growth factor. Although …