GHB pharmacology and toxicology: acute intoxication, concentrations in blood and urine in forensic cases and treatment of the withdrawal syndrome
The illicit recreational drug of abuse, γ-hydroxybutyrate (GHB) is a potent central nervous
system depressant and is often encountered during forensic investigations of living and …
system depressant and is often encountered during forensic investigations of living and …
Dilute-and-shoot-liquid chromatography-mass spectrometry for urine analysis in do** control and analytical toxicology
K Deventer, OJ Pozo, AG Verstraete… - TrAC Trends in Analytical …, 2014 - Elsevier
In the past 20 years, liquid chromatography-mass spectrometry (LC-MS) has become a
standard analytical technique in do** control and toxicology laboratories. Research …
standard analytical technique in do** control and toxicology laboratories. Research …
Simultaneous quantitation and discovery (SQUAD) analysis: combining the best of targeted and untargeted mass spectrometry-based metabolomics
Untargeted and targeted approaches are the traditional metabolomics workflows acquired
for a wider understanding of the metabolome under focus. Both approaches have their …
for a wider understanding of the metabolome under focus. Both approaches have their …
Mass spectrometry analysis of drugs of abuse: challenges and emerging strategies
Mass spectrometry has been the “gold standard” for drugs of abuse (DoA) analysis for many
decades because of the selectivity and sensitivity it affords. Recent progress in all aspects of …
decades because of the selectivity and sensitivity it affords. Recent progress in all aspects of …
Interpreting γ-hydroxybutyrate concentrations for clinical and forensic purposes
Introduction: γ-Hydroxybutyric acid is an endogenous substance, a therapeutic agent, and a
recreational drug of abuse. This psychoactive substance acts as a depressant of the central …
recreational drug of abuse. This psychoactive substance acts as a depressant of the central …
Metabolomics in clinical and forensic toxicology, sports anti‐do** and veterinary residues
B Keen, A Cawley, B Reedy, S Fu - Drug testing and analysis, 2022 - Wiley Online Library
Metabolomics is a multidisciplinary field providing workflows for complementary approaches
to conventional analytical determinations. It allows for the study of metabolically related …
to conventional analytical determinations. It allows for the study of metabolically related …
Gamma-hydroxybutyrate (GHB), 1, 4-butanediol (1, 4BD), and gamma-butyrolactone (GBL) intoxication: A state-of-the-art review
L Dufayet, S Bargel, A Bonnet, AK Boukerma… - Regulatory Toxicology …, 2023 - Elsevier
Abstract γ-hydroxybutyrate (GHB) is synthesized endogenously from γ-aminobutyric acid
(GABA) or exogenously from 1, 4-butanediol (butane-1, 4-diol; 1, 4-BD) or γ-butyrolactone …
(GABA) or exogenously from 1, 4-butanediol (butane-1, 4-diol; 1, 4-BD) or γ-butyrolactone …
Ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) for determination of GHB, precursors and metabolites in different …
Gamma-hydroxybutyric acid (GHB) acts as a precursor and metabolite of the inhibitory
central nervous system (CNS) neurotransmitter gamma-aminobutyric acid (GABA). Sodium …
central nervous system (CNS) neurotransmitter gamma-aminobutyric acid (GABA). Sodium …
Hair testing of GHB: an everlasting issue in forensic toxicology
Background: In this paper, the authors present a critical review of different studies regarding
hair testing of endogenous γ-hydroxybutyrate (GHB), concentrations in chronic users, and …
hair testing of endogenous γ-hydroxybutyrate (GHB), concentrations in chronic users, and …
Identification of new urinary gamma‐hydroxybutyric acid markers applying untargeted metabolomics analysis following placebo‐controlled administration to humans
AE Steuer, J Raeber, C Steuer, MI Boxler… - Drug testing and …, 2019 - Wiley Online Library
Gamma‐hydroxybutyrate (GHB) is a short‐chain fatty acid that occurs naturally in the
mammalian brain and is prescribed as a medication against narcolepsy or used as a drug of …
mammalian brain and is prescribed as a medication against narcolepsy or used as a drug of …