Over the last decades, the growing understanding on DNA damage response (DDR)
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …

For decades, radiotherapy and chemotherapy were the two only approaches exploiting DNA
repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major …

Phosphatidylinositol 3-kinases (PI3Ks) and phosphatidylinositol 3-kinase-related protein
kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell …

The DNA-PK holoenzyme is a fundamental element of the DNA damage response
machinery (DDR), which is responsible for cellular genomic stability. Consequently, and …

Ionizing radiation results in extensive damage to biological systems. The massive amount of
ionizing radiation from nuclear accidents, radiation therapy (RT), space exploration, and the …

The DNA-dependent protein kinase (DNA-PK) complex plays a pivotal role in non-
homologous end-joining (NHEJ) repair. We investigated the mechanism of NU7441, a …

Head and neck squamous cell carcinoma (HNSCC) is a significant cause of cancer deaths.
Cisplatin-based chemoradiotherapy is a standard of care for locally advanced disease. ATR …

Objective: Radiation therapy, one of the major treatments for liver cancer, causes DNA
damage and cell death. Since the liver cancer cells have a strong capacity to repair …

The most sensitive cell structure-a DNA molecule, is the common target of cancer therapy.
DNA damage response (controlled by enzymes from the phosphatidylinositol 3-kinase …

Platinum-based chemotherapy is the cornerstone of ovarian cancer treatment, and its
efficacy is dependent on the generation of DNA damage, with subsequent induction of …