Browning of the white adipose tissue regulation: New insights into nutritional and metabolic relevance in health and diseases

SA Machado, G Pasquarelli-do-Nascimento… - Nutrition & …, 2022‏ - Springer
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

The integrative biology of type 2 diabetes

M Roden, GI Shulman - Nature, 2019‏ - nature.com
Obesity and type 2 diabetes are the most frequent metabolic disorders, but their causes
remain largely unclear. Insulin resistance, the common underlying abnormality, results from …

The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic

L Geng, KSL Lam, A Xu - Nature Reviews Endocrinology, 2020‏ - nature.com
Abstract Fibroblast growth factor 21 (FGF21) is a stress-inducible hormone that has
important roles in regulating energy balance and glucose and lipid homeostasis through a …

[HTML][HTML] Mechanisms of insulin action and insulin resistance

MC Petersen, GI Shulman - Physiological reviews, 2018‏ - journals.physiology.org
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Metabolites as regulators of insulin sensitivity and metabolism

Q Yang, A Vijayakumar, BB Kahn - Nature reviews Molecular cell …, 2018‏ - nature.com
The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

[HTML][HTML] Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease

LL Baggio, DJ Drucker - Molecular metabolism, 2021‏ - Elsevier
Background Glucagon-like peptide-1 receptor (GLP-1R) agonists are approved for the
treatment of type 2 diabetes and obesity and elicit robust improvements in glycemic control …

[HTML][HTML] FGF21 as modulator of metabolism in health and disease

C Tezze, V Romanello, M Sandri - Frontiers in physiology, 2019‏ - frontiersin.org
Fibroblast growth factor 21 (FGF21) is a hormone that regulates important metabolic
pathways. FGF21 is expressed in several metabolically active organs and interacts with …

Mitohormesis

YW Cheng, J Liu, T Finkel - Cell metabolism, 2023‏ - cell.com
Perturbation of mitochondrial function can trigger a host of cellular responses that seek to
restore cellular metabolism, cytosolic proteostasis, and redox homeostasis. In some cases …

Metabolic messengers: FGF21

KH Flippo, MJ Potthoff - Nature metabolism, 2021‏ - nature.com
As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as
an endocrine hormone that signals to distinct targets throughout the body. Interest in …

Nutrition, infection and stunting: the roles of deficiencies of individual nutrients and foods, and of inflammation, as determinants of reduced linear growth of children

DJ Millward - Nutrition research reviews, 2017‏ - cambridge.org
The regulation of linear growth by nutritional and inflammatory influences is examined in
terms of growth-plate endochondral ossification, in order to better understand stunted growth …