The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …

Cognitive neuroscience studies in humans have enabled decades of impactful discoveries
but have primarily been limited to recording the brain activity of immobile participants in a …

Theta frequency (4–8 Hz) fluctuations of the local field potential have long been implicated
in learning and memory. Human studies of episodic memory, however, have provided mixed …

The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating …

The breadth and complexity of natural behaviors inspires awe. Understanding how our
perceptions, actions, and internal thoughts arise from evolved circuits in the brain has …

BACKGROUND Ever since Edward Tolman's proposal that comprehensive cognitive maps
underlie spatial navigation and, more generally, psychological functions, the question of …

The'cognitive map'hypothesis proposes that brain builds a unified representation of the
spatial environment to support memory and guide future action. Forty years of …

Viewpoints: how the hippocampus contributes to memory, navigation and cognition | Nature
Neuroscience Skip to main content Thank you for visiting nature.com. You are using a browser …

A significant body of work has investigated the effects of acute exercise, defined as a single
bout of physical activity, on mood and cognitive functions in humans. Several excellent …

Various cognitive functions have long been known to require the hippocampus. Recently,
progress has been made in identifying the hippocampal neural activity patterns that …