Engineering islets from stem cells for advanced therapies of diabetes
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
Towards a better understanding of diabetes mellitus using organoid models
BS Beydag-Tasöz, S Yennek… - Nature Reviews …, 2023 - nature.com
Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …
investigations and work in model organisms and cell lines. Organoid models for a wide …
[HTML][HTML] Generation of functional human pancreatic β cells in vitro
The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide
an unprecedented cell source for drug discovery and cell transplantation therapy in …
an unprecedented cell source for drug discovery and cell transplantation therapy in …
Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model
S Bauer, C Wennberg Huldt, KP Kanebratt, I Durieux… - Scientific reports, 2017 - nature.com
Human in vitro physiological models studying disease and drug treatment effects are
urgently needed as more relevant tools to identify new drug targets and therapies. We have …
urgently needed as more relevant tools to identify new drug targets and therapies. We have …
[HTML][HTML] Long-term expansion of pancreatic islet organoids from resident Procr+ progenitors
D Wang, J Wang, L Bai, H Pan, H Feng, H Clevers… - Cell, 2020 - cell.com
It has generally proven challenging to produce functional β cells in vitro. Here, we describe a
previously unidentified protein C receptor positive (Procr+) cell population in adult mouse …
previously unidentified protein C receptor positive (Procr+) cell population in adult mouse …
Organoid microphysiological system preserves pancreatic islet function within 3D matrix
Three-dimensional (3D) multicellular organoids recapitulate the native complexities of
human tissue better than traditional cellular monolayers. As organoids are insufficiently …
human tissue better than traditional cellular monolayers. As organoids are insufficiently …
In vivo–mimicking microfluidic perfusion culture of pancreatic islet spheroids
Native pancreatic islets interact with neighboring cells by establishing three-dimensional
(3D) structures, and are surrounded by perfusion at an interstitial flow level. However, flow …
(3D) structures, and are surrounded by perfusion at an interstitial flow level. However, flow …
Recent advances of biosensor-integrated organ-on-a-chip technologies for diagnostics and therapeutics
Conventional preclinical evaluation implemented in 2D monolayer cultures falls short with
multiorgan interactions, while animal systems lack the specificity of the human species …
multiorgan interactions, while animal systems lack the specificity of the human species …
Type 1 Diabetes Mellitus: A Review on Advances and Challenges in Creating Insulin Producing Devices
SM Rodrigues Oliveira, A Rebocho, E Ahmadpour… - Micromachines, 2023 - mdpi.com
Type 1 diabetes mellitus (T1DM) is the most common autoimmune chronic disease in young
patients. It is caused by the destruction of pancreatic endocrine β-cells that produce insulin …
patients. It is caused by the destruction of pancreatic endocrine β-cells that produce insulin …
Modelling the endocrine pancreas in health and disease
Diabetes mellitus is a multifactorial disease affecting increasing numbers of patients
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss …
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss …