Ketamine and ketamine metabolite pharmacology: insights into therapeutic mechanisms
Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …
Photocatalytic performance of g-C3N4 based nanocomposites for effective degradation/removal of dyes from water and wastewater
The world is concerned about the hazardous effect of dyes that pose a threat to the
ecosystem. It is therefore essential to remove these dyes from the aquatic system by using …
ecosystem. It is therefore essential to remove these dyes from the aquatic system by using …
Design and development of novel composites containing nickel ferrites supported on activated carbon derived from agricultural wastes and its application in water …
Recently, efficient decontamination of water and wastewater have attracted global attention
due to the deficiency in the world's water sources. Herein, activated carbon (AC) derived …
due to the deficiency in the world's water sources. Herein, activated carbon (AC) derived …
[HTML][HTML] Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review
L Schiffer, L Barnard, ES Baranowski… - The Journal of steroid …, 2019 - Elsevier
Advances in technology have allowed for the sensitive, specific, and simultaneous
quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites …
quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites …
[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
Adsorption of hazardous dyes on functionalized multiwalled carbon nanotubes in single and binary systems: Experimental study and physicochemical interpretation of …
The crystal violet (CV) and rhodamine B (RhB) dyes were selected in this paper to study
their adsorption on functionalized multiwalled carbon nanotubes (MCN). Adsorbent …
their adsorption on functionalized multiwalled carbon nanotubes (MCN). Adsorbent …
Research progress on berberine with a special focus on its oral bioavailability
CS Liu, YR Zheng, YF Zhang, XY Long - Fitoterapia, 2016 - Elsevier
The natural product berberine (BBR) has become a potential drug in the treatment of
diabetes, hyperlipidemia, and cancer. However, the oral delivery of BBR is challenged by its …
diabetes, hyperlipidemia, and cancer. However, the oral delivery of BBR is challenged by its …
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
P Kuehl, J Zhang, Y Lin, J Lamba, M Assem… - Nature …, 2001 - nature.com
Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating
steroid levels and responses to half of all oxidatively metabolized drugs. CYP3A activity is …
steroid levels and responses to half of all oxidatively metabolized drugs. CYP3A activity is …
Metabolism and disposition kinetics of nicotine
J Hukkanen, P Jacob III, NL Benowitz - Pharmacological reviews, 2005 - Elsevier
Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for
smoking cessation, a potential medication for several diseases, and a useful probe drug for …
smoking cessation, a potential medication for several diseases, and a useful probe drug for …
Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction
M Martignoni, GMM Groothuis… - Expert opinion on drug …, 2006 - Taylor & Francis
Animal models are commonly used in the preclinical development of new drugs to predict
the metabolic behaviour of new compounds in humans. It is, however, important to realise …
the metabolic behaviour of new compounds in humans. It is, however, important to realise …