The abundant existence of proteins and regions that possess specific functions without
being uniquely folded into unique 3D structures has become accepted by a significant …

How do organisms assess the degree of completion of a large structure, especially an
extracellular structure such as a flagellum? Bacteria can do this. Mutants that lack key …

The dominant view of protein structure-function is that an amino acid sequence specifies a
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …

The bacterial flagellar filament is a helical propeller for bacterial locomotion. It is a helical
assembly of a single protein, flagellin, and its tubular structure is formed by 11 protofilaments …

Flagella contribute to the virulence of pathogenic bacteria through chemotaxis, adhesion to
and invasion of host surfaces. Flagellin is the structural protein that forms the major portion …

The bacterial flagellum is a complex and dynamic nanomachine that propels bacteria
through liquids. It consists of a basal body, a hook, and a long filament. The flagellar filament …

Robust innate immune detection of rapidly evolving pathogens is critical for host defense.
Nucleotide-binding domain leucine-rich repeat (NLR) proteins function as cytosolic innate …

The dominant view in protein science is that a three-dimensional 3-D) structure is a
prerequisite for protein function. In contrast to this dominant view, there are many …

Publisher Summary This chapter illustrates that protein disorder is encoded by the amino
acid sequence and that protein disorder is essential for many important biological functions …

Bacterial flagella, unlike eukaryotic flagella, are largely external to the cell and therefore
many of their subunits have to be exported. Export is ATP-driven. In Salmonella, the …