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Targeting autophagy in disease: established and new strategies
Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
Research progress of mTOR inhibitors
Y Chen, X Zhou - European journal of medicinal chemistry, 2020 - Elsevier
Mammalian target of rapamycin (mTOR) is a highly conserved Serine/Threonine (Ser/Thr)
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …
Glucose-driven TOR–FIE–PRC2 signalling controls plant development
Nutrients and energy have emerged as central modulators of developmental programmes in
plants and animals,–. The evolutionarily conserved target of rapamycin (TOR) kinase is a …
plants and animals,–. The evolutionarily conserved target of rapamycin (TOR) kinase is a …
Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer
Abstract While PI3K/AKT/mTOR pathway is altered in a variety of cancers including non
small cell lung cancer, abnormalities in this pathway are more common in squamous cell …
small cell lung cancer, abnormalities in this pathway are more common in squamous cell …
mTOR inhibitors in cancer therapy
The mammalian target of rapamycin, mTOR, plays key roles in cell growth and proliferation,
acting at the catalytic subunit of two protein kinase complexes: mTOR complexes 1 and 2 …
acting at the catalytic subunit of two protein kinase complexes: mTOR complexes 1 and 2 …
Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application …
Autophagy is an intracellular degradation pathway essential for cellular and energy
homoeostasis. It functions in the clearance of misfolded proteins and damaged organelles …
homoeostasis. It functions in the clearance of misfolded proteins and damaged organelles …
[HTML][HTML] Progress towards a clinically-successful ATR inhibitor for cancer therapy
The DNA damage response (DDR) is now known to play an important role in both cancer
development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia …
development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia …
Autophagy in health and disease: From molecular mechanisms to therapeutic target
Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …
Roles of mTOR complexes in the kidney: implications for renal disease and transplantation
The mTOR pathway has a central role in the regulation of cell metabolism, growth and
proliferation. Studies involving selective gene targeting of mTOR complexes (mTORC1 and …
proliferation. Studies involving selective gene targeting of mTOR complexes (mTORC1 and …
Targeting ATM and ATR for cancer therapeutics: Inhibitors in clinic
Highlights•Genome sequencing has made personalized therapy the preferred cancer
therapeutic approach.•In the past decade, the relevance of targeting DDR kinases for cancer …
therapeutic approach.•In the past decade, the relevance of targeting DDR kinases for cancer …