A practical guide to amplicon and metagenomic analysis of microbiome data
Advances in high-throughput sequencing (HTS) have fostered rapid developments in the
field of microbiome research, and massive microbiome datasets are now being generated …
field of microbiome research, and massive microbiome datasets are now being generated …
Microbial signatures of health, gingivitis, and periodontitis
The subgingival crevice harbors diverse microbial communities. Shifts in the composition of
these communities occur with the development of gingivitis and periodontitis, which are …
these communities occur with the development of gingivitis and periodontitis, which are …
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer
Aside from PD-L1 expression, biomarkers of response to immune checkpoint inhibitors (ICIs)
in non-small-cell lung cancer (NSCLC) are needed. In a previous retrospective analysis, we …
in non-small-cell lung cancer (NSCLC) are needed. In a previous retrospective analysis, we …
Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1
Ample evidence indicates that the gut microbiome is a tumor-extrinsic factor associated with
antitumor response to anti-programmed cell death protein-1 (PD-1) therapy, but …
antitumor response to anti-programmed cell death protein-1 (PD-1) therapy, but …
Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses
Increasing evidence implicates the tumor microbiota as a factor that can influence cancer
progression. In patients with colorectal cancer (CRC), we found that pre-resection antibiotics …
progression. In patients with colorectal cancer (CRC), we found that pre-resection antibiotics …
Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota
K Hosomi, M Saito, J Park, H Murakami… - Nature …, 2022 - nature.com
The gut microbiome is an important determinant in various diseases. Here we perform a
cross-sectional study of Japanese adults and identify the Blautia genus, especially B …
cross-sectional study of Japanese adults and identify the Blautia genus, especially B …
Diet-driven microbial ecology underpins associations between cancer immunotherapy outcomes and the gut microbiome
The gut microbiota shapes the response to immune checkpoint inhibitors (ICIs) in cancer,
however dietary and geographic influences have not been well-studied in prospective trials …
however dietary and geographic influences have not been well-studied in prospective trials …
Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis
Z Wu, S Huang, T Li, N Li, D Han, B Zhang, ZZ Xu… - Microbiome, 2021 - Springer
Background Alteration of the gut microbiota may contribute to the development of
inflammatory bowel disease (IBD). Epigallocatechin-3-gallate (EGCG), a major bioactive …
inflammatory bowel disease (IBD). Epigallocatechin-3-gallate (EGCG), a major bioactive …
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy
M Smith, A Dai, G Ghilardi, KV Amelsberg, SM Devlin… - Nature medicine, 2022 - nature.com
Anti-CD19 chimeric antigen receptor (CAR) T cell therapy has led to unprecedented
responses in patients with high-risk hematologic malignancies. However, up to 60% of …
responses in patients with high-risk hematologic malignancies. However, up to 60% of …
Microbiome differential abundance methods produce different results across 38 datasets
Identifying differentially abundant microbes is a common goal of microbiome studies.
Multiple methods are used interchangeably for this purpose in the literature. Yet, there are …
Multiple methods are used interchangeably for this purpose in the literature. Yet, there are …