Surgery and stress promote cancer metastasis: new outlooks on perioperative mediating mechanisms and immune involvement

E Neeman, S Ben-Eliyahu - Brain, behavior, and immunity, 2013 - Elsevier
Surgery for the removal of a primary tumor presents an opportunity to eradicate cancer or
arrest its progression, but is also believed to promote the outbreak of pre-existing …

Surgery as a risk factor for breast cancer recurrence and metastasis: mediating mechanisms and clinical prophylactic approaches

Y Goldfarb, S Ben-Eliyahu - Breast disease, 2007 - content.iospress.com
Surgical resection of the primary tumor is a necessary and effective treatment for breast
cancer patients. For various reasons discussed, we believe that the short postoperative …

Perioperative use of β-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis

M Benish, I Bartal, Y Goldfarb, B Levi… - Annals of surgical …, 2008 - Springer
Background COX inhibitors and β-blockers were recently suggested to reduce cancer
progression through inhibition of tumor proliferation and growth factor secretion, induction of …

Do Stress Responses Promote Leukemia Progression? An Animal Study Suggesting a Role for Epinephrine and Prostaglandin-E2 through Reduced NK Activity

S Inbar, E Neeman, R Avraham, M Benish, E Rosenne… - PloS one, 2011 - journals.plos.org
In leukemia patients, stress and anxiety were suggested to predict poorer prognosis.
Oncological patients experience ample physiological and psychological stress, potentially …

Impact of brief exercise on peripheral blood NK cell gene and microRNA expression in young adults

S Radom-Aizik, F Zaldivar… - Journal of applied …, 2013 - journals.physiology.org
Natural killers (NK) cells are unique innate immune cells that increase up to fivefold in the
circulating blood with brief exercise and are known to play a key role in first-response …

Does analgesia and condition influence immunity after surgery? Effects of fentanyl, ketamine and clonidine on natural killer activity at different ages

P Forget, V Collet, P Lavand'homme… - European Journal of …, 2010 - journals.lww.com
Materials and methods Rats undergoing laparotomy under sevoflurane anaesthesia were
assigned to receive saline, fentanyl (40 μg kg− 1), clonidine (10 μg kg− 1) or ketamine (10 …

In vivo suppression of NK cell cytotoxicity by stress and surgery: glucocorticoids have a minor role compared to catecholamines and prostaglandins

E Rosenne, L Sorski, L Shaashua, E Neeman… - Brain, behavior, and …, 2014 - Elsevier
Most in vitro and ex-vivo studies indicate a profound suppression of NK cell cytotoxicity
(NKCC) by glucocorticoids; while catecholamines and prostaglandins were reported both to …

The influence of myeloid‐derived suppressor cells on angiogenesis and tumor growth after cancer surgery

J Wang, X Su, L Yang, F Qiao, Y Fang… - … journal of cancer, 2016 - Wiley Online Library
While myeloid‐derived suppressor cells (MDSCs) have been reported to participate in the
promotion of angiogenesis and tumor growth, little is known about their presence and …

Single dose of dexamethasone is not associated with postoperative recurrence and mortality in breast cancer patients: a propensity-matched cohort study

MH Kim, DW Kim, S Park, JH Kim, KY Lee, J Hwang… - BMC cancer, 2019 - Springer
Background Dexamethasone is widely used in cancer patients despite the concern that
perioperative glucocorticoids may potentially cause immunosuppression. However, studies …

Autologous serum collected 1 h post-exercise enhances natural killer cell cytotoxicity

P Gupta, AB Bigley, M Markofski, M Laughlin… - Brain, behavior, and …, 2018 - Elsevier
Natural Killer cells are cytotoxic lymphocytes that recognize and eliminate tumor cells.
Exercise enhances NK cell cytotoxic activity (NKCA), yet the underlying mechanisms are not …