Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …

MicroRNAs (miRNAs) are conserved, short, non-coding RNAs that play a crucial role in the
post-transcriptional regulation of gene expression. They have been implicated in the …

Being the largest internal organ of the human body with the unique ability of self-
regeneration, the liver is involved in a wide variety of vital functions that require highly …

Hepatitis B virus (HBV) infection remains a major public health concern worldwide with
about 257 million individuals chronically infected. Current therapies can effectively control …

Liver cancer is the fourth leading cause of cancer deaths globally, of which hepatocellular
carcinoma (HCC) is the major subtype. Viral hepatitis B and C infections, alcohol abuse, and …

As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to
viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular …

Serum levels of liver enzymes, such as alanine transaminase, aspartate transaminase, and
α-fetoprotein, provide insight into liver function and are used during treatment of liver …

miR-122, a completely conserved liver-specific miRNA in vertebrates, is essential for the
maintenance of liver homeostasis. This 22 nucleotide RNA regulates diverse functions such …

The study of miRNAs started in 1993, when Lee et al. observed their involvement in the
downregulation of a crucial protein known as LIN-14 in the nematode Caenorhabditis …

Upon recognition of viral components by pattern recognition receptors, such as the toll-like
receptors (TLRs) and retinoic acid-inducible gene I (RIG-I)-like helicases, cells are activated …