The mathematical concept of fluorescence correlation spectroscopy (FCS) 1 (1) emerged
from quasi-elastic light scattering (QELS) spectroscopy (2) in the early 1970s. Compared to …

Fluorescence correlation spectroscopy (FCS) is a powerful technique to measure
concentrations, mobilities, and interactions of fluorescent biomolecules. It can be applied to …

The success of fluorescence experiments requires attention to experimental details and an
understanding of the instrumentation. There are also many potential artifacts that can distort …

Dual-color fluorescence cross-correlation spectroscopy (FCCS) allows for the determination
of molecular mobility and concentrations and for the quantitative analysis of molecular …

The standard deviation (SD) in fluorescence correlation spectroscopy (FCS) has been
mostly neglected in applications. However, the knowledge of the correct SD is necessary for …

Much has been learned about the role of exofacial phosphatidylserine (PS) in apoptosis and
blood clotting using annexin V. However, because annexins are impermeant and unable to …

Chemical signalling is the primary means by which cells communicate in the embryo. The
underlying principle refers to a group of ligand-producing cells and a group of cells that …

Chemical and biological labeling is fundamental for the elucidation of the function of
proteins within biochemical cellular networks. In particular, fluorescent probes allow …

Abstract (Chemical Equation Presented) HDM2 regulates p53 by binding to its
transactivation domain and promoting its ubiquitin-dependent degradation. Crystallographic …

Receptor–ligand interactions play a crucial role in biological systems and their
measurement forms an important part of modern pharmaceutical development. Numerous …