Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …

Conspectus Protein–protein interactions (PPIs) are ubiquitous in biological systems and
often misregulated in disease. As such, specific PPI modulators are desirable to unravel …

Inhibiting protein-protein interactions (PPIs) with synthetic molecules remains a frontier of
chemical biology. Many PPIs have been successfully targeted by mimicking α-helices at …

Protein–protein interactions (PPIs) are vital to all biological processes. These interactions
are often dynamic, sometimes transient, typically occur over large topographically shallow …

The development of inhibitors for protein–protein interactions frequently involves the mimicry
of secondary structure motifs. While helical protein–protein interactions have been heavily …

Protein secondary and tertiary structure mimics have served as model systems to probe
biophysical parameters that guide protein folding and as attractive reagents to modulate …

The canonical Wingless-related integration site signaling pathway plays a critical role in
human physiology, and its dysregulation can lead to an array of diseases. β-Catenin is a …

Disruption of protein–protein interactions is medicinally important. Interface helices may be
mimicked in helical probes featuring enhanced rigidities, binding to protein targets …

Protein-protein interactions (PPIs) play a pivotal role in extensive biological processes and
are thus crucial to human health and the development of disease states. Due to their critical …

The modulation of protein–protein interactions (PPIs) by means of creating or stabilizing
secondary structure conformations is a rapidly growing area of research. Recent success in …