What's the buzz? The neuroscience and the treatment of tinnitus

A Henton, T Tzounopoulos - Physiological reviews, 2021 - journals.physiology.org
Tinnitus is a pervasive public health issue that affects∼ 15% of the United States population.
Similar estimates have also been shown on a global scale, with similar prevalence found in …

Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss

K Hough, CA Verschuur, C Cunningham, TA Newman - Glia, 2022 - Wiley Online Library
Macrophages are abundant in the cochlea; however, their role in hearing loss is not well
understood. Insults to the cochlea, such as noise or insertion of a cochlear implant, cause an …

Noise‐induced hearing loss: updates on molecular targets and potential interventions

H Mao, Y Chen - Neural Plasticity, 2021 - Wiley Online Library
Noise overexposure leads to hair cell loss, synaptic ribbon reduction, and auditory nerve
deterioration, resulting in transient or permanent hearing loss depending on the exposure …

Antioxidant therapy against oxidative damage of the inner ear: Protection and preconditioning

JH Pak, Y Kim, J Yi, JW Chung - Antioxidants, 2020 - mdpi.com
Oxidative stress is an important mechanism underlying cellular damage of the inner ear,
resulting in hearing loss. In order to prevent hearing loss, several types of antioxidants have …

[HTML][HTML] Thirty risk factors for Alzheimer's Disease Unified by a common neuroimmune–neuroinflammation mechanism

DF Weaver - Brain Sciences, 2023 - mdpi.com
One of the major obstacles confronting the formulation of a mechanistic understanding for
Alzheimer's disease (AD) is its immense complexity—a complexity that traverses the full …

Development of ebselen for the treatment of sensorineural hearing loss and tinnitus

J Kil, EE Harruff, RJ Longenecker - Hearing Research, 2022 - Elsevier
The global impact of hearing loss and related auditory dysfunction including tinnitus and
hyperacusis on human health is significant and growing. A substantial body of literature has …

Characterization of anxiety-like behaviors and neural circuitry following chronic moderate noise exposure in mice

X Peng, Y Mao, Y Tai, B Luo, Q Dai… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Commonly encountered nontraumatic, moderate noise is increasingly
implicated in anxiety; however, the neural substrates underlying this process remain …