Successfully engineering a functional, human, myocardial pump would represent a
therapeutic alternative for the millions of patients with end-stage heart disease and provide …

It is now well recognized that many lifesaving oncology drugs may adversely affect the heart
and cardiovascular system, including causing irreversible cardiac injury that can result in …

Tissue engineered cardiac patches have great potential as a therapeutic treatment for
myocardial infarction (MI). However, for successful integration with the native tissue and …

Human induced pluripotent stem cells (hiPSCs) represent an almost limitless source of cells
for disease modelling and drug screening applications. Here we established an efficient and …

Cardiovascular disease is a significant cause of death in humans. Various models are
necessary for the study of cardiovascular diseases, but once cellular and animal models …

Abstract Background Cardiovascular diseases (CVDs) have the highest mortality worldwide.
Human pluripotent stem cells (hPSCs) and their cardiomyocyte derivatives (hPSC-CMs) …

Human pluripotent stem cells (hPSCs) offer a multifaceted platform to study cardiac
developmental biology, understand disease mechanisms, and develop novel therapies …

The development of bioprocesses capable of producing large numbers of human induced
pluripotent stem cells (hiPSC) in a robust and safe manner is critical for the application of …

A primary limitation in the use of pluripotent stem cell‐derived cardiomyocytes (PSC‐CMs)
for both patient health and scientific investigation is the failure of these cells to achieve full …

The vast potential of human induced pluripotent stem-cell-derived cardiomyocytes (hiPSC-
CMs) in preclinical models of cardiac pathologies, precision medicine, and drug screening …