[PDF][PDF] Biofilms: formation, research models, potential targets, and methods for prevention and treatment

Y Su, JT Yrastorza, M Matis, J Cusick, S Zhao… - Advanced …, 2022 - Wiley Online Library
Due to the continuous rise in biofilm‐related infections, biofilms seriously threaten human
health. The formation of biofilms makes conventional antibiotics ineffective and dampens …

Peptide design principles for antimicrobial applications

MDT Torres, S Sothiselvam, TK Lu… - Journal of molecular …, 2019 - Elsevier
The increased incidence of bacterial resistance to available antibiotics represents a major
global health problem and highlights the need for novel anti-infective therapies …

Mining for encrypted peptide antibiotics in the human proteome

MDT Torres, MCR Melo, L Flowers… - Nature Biomedical …, 2022 - nature.com
The emergence of drug-resistant bacteria calls for the discovery of new antibiotics. Yet, for
decades, traditional discovery strategies have not yielded new classes of antimicrobial …

Computer-aided design of antimicrobial peptides: are we generating effective drug candidates?

MH Cardoso, RQ Orozco, SB Rezende… - Frontiers in …, 2020 - frontiersin.org
Antimicrobial peptides (AMPs), especially antibacterial peptides, have been widely
investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally …

Structure-function-guided exploration of the antimicrobial peptide polybia-CP identifies activity determinants and generates synthetic therapeutic candidates

MDT Torres, CN Pedron, Y Higashikuni… - Communications …, 2018 - nature.com
Antimicrobial peptides (AMPs) constitute promising alternatives to classical antibiotics for the
treatment of drug-resistant infections, which are a rapidly emerging global health challenge …

Synthetic biology and computer-based frameworks for antimicrobial peptide discovery

MDT Torres, J Cao, OL Franco, TK Lu… - ACS …, 2021 - ACS Publications
Antibiotic resistance is one of the greatest challenges of our time. This global health problem
originated from a paucity of truly effective antibiotic classes and an increased incidence of …

Repurposing a peptide toxin from wasp venom into antiinfectives with dual antimicrobial and immunomodulatory properties

ON Silva, MDT Torres, J Cao, ESF Alves… - Proceedings of the …, 2020 - pnas.org
Novel antibiotics are urgently needed to combat multidrug-resistant pathogens. Venoms
represent previously untapped sources of novel drugs. Here we repurposed mastoparan-L …

Unnatural amino acids: Promising implications for the development of new antimicrobial peptides

X Wang, X Yang, Q Wang, D Meng - Critical Reviews in …, 2023 - Taylor & Francis
The increasing incidence and rapid spread of bacterial resistance to conventional antibiotics
are a serious global threat to public health, highlighting the need to develop new …

Reprogramming biological peptides to combat infectious diseases

MDT Torres, C de la Fuente-Nunez - Chemical Communications, 2019 - pubs.rsc.org
With the rapid spread of resistance among parasites and bacterial pathogens, antibiotic-
resistant infections have drawn much attention worldwide. Consequently, there is an urgent …