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New developments in RiPP discovery, enzymology and engineering
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
Ynamide coupling reagents: origin and advances
L Hu, J Zhao - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus Since the pioneering work of Curtius and Fischer, chemical peptide synthesis
has witnessed a century's development and evolved into a routine technology. However, it is …
has witnessed a century's development and evolved into a routine technology. However, it is …
Genome mining methods to discover bioactive natural products
Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …
organisms in publicly accessible databases, scientists have an unprecedented opportunity …
Structure of the bacterial ribosome at 2 Å resolution
Using cryo-electron microscopy (cryo-EM), we determined the structure of the Escherichia
coli 70S ribosome with a global resolution of 2.0 Å. The maps reveal unambiguous …
coli 70S ribosome with a global resolution of 2.0 Å. The maps reveal unambiguous …
Decoding directing groups and their pivotal role in C− H activation
K Murali, LA Machado, RL Carvalho… - … A European Journal, 2021 - Wiley Online Library
Synthetic organic chemistry has witnessed a plethora of functionalization and
defunctionalization strategies. In this regard, C− H functionalization has been at the forefront …
defunctionalization strategies. In this regard, C− H functionalization has been at the forefront …
Spectroscopic characterization (IR, UV-Vis), and HOMO-LUMO, MEP, NLO, NBO analysis and the antifungal activity for 4-bromo-N-(2-nitrophenyl) benzamide; using …
In this study, the density functional theory was used to explore the spectral and electronic
properties of the title molecule, as well as a molecular docking technique to evaluate its …
properties of the title molecule, as well as a molecular docking technique to evaluate its …
Site-selective modification of peptide backbones
A Boto, CC González, D Hernández… - Organic Chemistry …, 2021 - pubs.rsc.org
The site-selective modification of peptide backbones allows an outstanding fine-tuning of
peptide conformation, folding ability, and physico-chemical and biological properties …
peptide conformation, folding ability, and physico-chemical and biological properties …
Construction of hybrid ionic liquid‐catalysts for the highly effective conversion of H2S by nitriles into thioamides
Described herein presents a kind of multisite hybrid ionic liquid‐catalysts and establishes a
novel strategy for H2S utilization, which has been characterized by multiaspects to reveal …
novel strategy for H2S utilization, which has been characterized by multiaspects to reveal …
Thioamides in medicinal chemistry and as small molecule therapeutic agents
G Huang, T Cierpicki, J Grembecka - European Journal of Medicinal …, 2024 - Elsevier
Thioamides, which are fascinating isosteres of amides, have garnered significant attention in
drug discovery and medicinal chemistry programs, spanning peptides and small molecule …
drug discovery and medicinal chemistry programs, spanning peptides and small molecule …
Construction of thioamide peptides from chiral amino acids
Y Liao, S Zhang, X Jiang - Angewandte Chemie International …, 2023 - Wiley Online Library
Thioamide peptides were synthesized in a straightforward one‐pot process via the linkage
of diverse natural amino acids in the presence of thiolphosphonate and trichlorosilane …
of diverse natural amino acids in the presence of thiolphosphonate and trichlorosilane …