Taxol (paclitaxel), the most well-known taxane diterpenoid, is the best-selling natural-source
anticancer drug ever produced and one of the most common prescriptions in the treatment of …

Plants have had an essential role in the folklore of ancient cultures. In addition to the use as
food and spices, plants have also been utilized as medicines for over 5000 years. It is …

A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

Azulene is an aromatic hydrocarbon that possesses a unique chemical structure and
interesting biological properties. Azulene derivatives, including guaiazulene or …

Throughout history, natural products have afforded a rich source of compounds that have
found many applications in the fields of medicine, pharmacy and biology. Within the sphere …

Natural products have been the mainstay of cancer chemotherapy for the past 30 years.
However, the quickening pace of (aberrant) gene identification, and the new technologies of …

The addition of a 1, 3-dipole to an alkene or alkyne is a prominent transformation in organic
synthesis. 1 Over the past two decades the intense study of enantioselective 1, 3-dipolar …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Numerous variations on structural motifs exist within pharmaceutical compounds that have
entered the clinic. These variations have amounted over many decades based on years of …

A stereodivergent synthesis of chiral β-lactams with contiguous tertiary/quaternary/tertiary
stereocenters has been achieved by a Cu/Ir-catalyzed three-component interrupted …